Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.53 |
| ▸ | CTSL | P07711 | 4/20 | 0.52 |
| ▸ | CTSB | P07858 | 4/20 | 0.52 |
| ▸ | TACR2 | P21452 | 3/20 | 0.47 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.46 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.46 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.46 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.46 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.46 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.46 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.46 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.46 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.46 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.46 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.46 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441871 | 1.00 | CTSS (0.53) | CTSSCTSLCTSBTACR2PSMB11 | |
| SCHEMBL10555105 | 0.93 | CTSL (0.56) | CTSSCTSLCTSBTACR2PSMB11 | |
| SCHEMBL9417286 | 0.90 | QRFPR (0.46) | CTSSCTSLCTSBPOLBCTSK | |
| SCHEMBL7908157 | 0.87 | CTSL (0.39) | CTSSCTSLCTSBTACR2PSMB11 | |
| SCHEMBL26019659 | 0.87 | CTSL (0.39) | CTSSCTSLCTSBTACR2PSMB11 | |
| SCHEMBL9417413 | 0.86 | REN (0.51) | CTSSCTSL | |
| SCHEMBL7290351 | 0.86 | REN (0.51) | CTSSCTSL | |
| SCHEMBL7431573 | 0.86 | KMT2A (0.43) | CTSLPOLB | |
| SCHEMBL9417281 | 0.86 | CTSL (0.46) | CTSSCTSLCTSBPOLB | |
| SCHEMBL9417433 | 0.86 | MMP8 (0.45) | CTSSCTSLCTSBTACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |