Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286824 | 0.91 | HRH4 (0.42) | SMN1; SMN2CHRM2GAAL3MBTL1HRH4 | |
| SCHEMBL5093305 | 0.85 | POLB (0.48) | POLBHRH4LMNAKDM4ETDP1 | |
| SCHEMBL7287123 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2CHRM2POLBGAAL3MBTL1 | |
| SCHEMBL7296105 | 0.80 | NPBWR1 (0.45) | SMN1; SMN2CHRM2GAAL3MBTL1HRH4 | |
| SCHEMBL7293000 | 0.78 | NPBWR1 (0.48) | L3MBTL1LMNATDP1THRBNPBWR1 | |
| SCHEMBL7295548 | 0.77 | L3MBTL1 (0.43) | SMN1; SMN2CHRM2GAAL3MBTL1HRH4 | |
| SCHEMBL5099978 | 0.74 | ALDH1A1 (0.42) | POLBL3MBTL1LMNAKDM4ETDP1 | |
| SCHEMBL7297342 | 0.72 | CXCR4 (0.45) | SMN1; SMN2CHRM2KDM4ETDP1THRB | |
| SCHEMBL4418818 | 0.72 | CHRM2 (0.51) | SMN1; SMN2CHRM2GAAL3MBTL1HRH4 | |
| SCHEMBL7289329 | 0.71 | TMEM97 (0.46) | SMN1; SMN2CHRM2POLBTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810220-B1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6258953-B1 | Arylacrylamide derivatives | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0810220-A1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER INC. (US) | 1997-12-03 | — | — | EP | disclosed |