Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295548 | 0.90 | L3MBTL1 (0.43) | NPBWR1MCHR1SMN1; SMN2CHRM2GAA | |
| SCHEMBL7287123 | 0.86 | SMN1; SMN2 (0.44) | NPBWR1MCHR1SMN1; SMN2CHRM2TP53 | |
| SCHEMBL7296089 | 0.80 | NPBWR1 (0.52) | NPBWR1MCHR1TP53MAPTL3MBTL1 | |
| SCHEMBL7293003 | 0.80 | SMN1; SMN2 (0.45) | NPBWR1MCHR1SMN1; SMN2CHRM2TP53 | |
| SCHEMBL7286824 | 0.76 | HRH4 (0.42) | NPBWR1MCHR1SMN1; SMN2CHRM2TP53 | |
| SCHEMBL4418818 | 0.71 | CHRM2 (0.51) | SMN1; SMN2CHRM2GAAL3MBTL1TMEM97 | |
| SCHEMBL7284217 | 0.70 | KMT2A (0.52) | NPBWR1MCHR1SMN1; SMN2TP53MAPT | |
| SCHEMBL7295538 | 0.70 | L3MBTL1 (0.59) | NPBWR1MCHR1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL7284221 | 0.70 | KMT2A (0.52) | NPBWR1MCHR1SMN1; SMN2TP53MAPT | |
| SCHEMBL7294695 | 0.69 | NPBWR1 (0.47) | NPBWR1MCHR1GAAL3MBTL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810220-B1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6258953-B1 | Arylacrylamide derivatives | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0810220-A1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER INC. (US) | 1997-12-03 | — | — | EP | disclosed |