Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10076575 | 0.81 | CASP3 (0.41) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL24448592 | 0.75 | KMT2A (0.36) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL21895802 | 0.75 | TLR2 (0.45) | MDM4TP53CASP3MDM2 | |
| SCHEMBL20839708 | 0.75 | MDM4 (0.47) | MDM4TP53CASP3MDM2KMT2A | |
| SCHEMBL24633696 | 0.74 | MDM4 (0.46) | MDM4TP53CASP3MDM2 | |
| SCHEMBL10051474 | 0.73 | KMT2A (0.37) | CASP3PIN1KMT2A | |
| SCHEMBL1414413 | 0.73 | MDM4 (0.44) | MDM4TP53CASP3MDM2KMT2A | |
| SCHEMBL1414410 | 0.73 | MDM4 (0.44) | MDM4TP53CASP3MDM2KMT2A | |
| SCHEMBL23395771 | 0.72 | CASP3 (0.40) | MDM4TP53CASP3PIN1MDM2 | |
| SCHEMBL26761659 | 0.72 | MDM4 (0.38) | MDM4TP53CASP3MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011156557-A2 | COMPOUNDS ACTIVE AT THE NEUROTENSIN RECEPTOR | THOMAS JAMES B (US) | 2011-12-15 | — | — | WO | disclosed |