Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 13/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303389 | 0.86 | DHPS (0.81) | DHPSALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL4071996 | 0.85 | DHPS (0.67) | DHPSGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28589605 | 0.80 | DHPS (0.82) | DHPS | |
| SCHEMBL7700308 | 0.80 | DHPS (0.51) | DHPSALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL28577446 | 0.80 | DHPS (0.83) | DHPSMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28581580 | 0.79 | DHPS (0.82) | DHPS | |
| SCHEMBL28584053 | 0.79 | DHPS (0.82) | DHPS | |
| SCHEMBL7293762 | 0.79 | DHPS (0.82) | DHPSALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL29770374 | 0.79 | DHPS (0.58) | DHPS | |
| SCHEMBL618135 | 0.79 | DHPS (0.58) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |