Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 14/20 | 0.51 |
| ▸ | EDNRB | P24530 | 3/20 | 0.44 |
| ▸ | EDNRA | P25101 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698527 | 0.92 | DHPS (0.65) | DHPS | |
| SCHEMBL7698526 | 0.88 | DHPS (0.46) | DHPSEDNRBEDNRA | |
| SCHEMBL9423908 | 0.85 | LMNA (0.55) | DHPSLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL7694584 | 0.84 | EDNRB (0.44) | DHPSEDNRBEDNRALMNAMEN1 | |
| SCHEMBL29770374 | 0.80 | DHPS (0.58) | DHPSEDNRBEDNRA | |
| SCHEMBL618135 | 0.80 | DHPS (0.58) | DHPSEDNRBEDNRA | |
| SCHEMBL7294963 | 0.80 | DHPS (0.62) | DHPSMEN1KMT2AALDH1A1GAA | |
| SCHEMBL14380592 | 0.79 | EDNRB (0.70) | EDNRBEDNRA | |
| SCHEMBL4071996 | 0.78 | DHPS (0.67) | DHPSEDNRBEDNRAGAA | |
| SCHEMBL14380586 | 0.78 | EDNRB (0.58) | EDNRBEDNRALMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285549-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-10-23 | — | — | US | disclosed |
| US-7285549-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-10-23 | — | — | US | disclosed |
| WO-2002083650-A1 | NOVEL SULFONYLAMINO-PYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-10-24 | — | — | WO | disclosed |