Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 7/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294686 | 0.88 | NPBWR1 (0.52) | NPBWR1MCHR1L3MBTL1NPC1MC4R | |
| SCHEMBL7295243 | 0.79 | NPBWR1 (0.43) | NPBWR1MCHR1L3MBTL1NPC1MC4R | |
| SCHEMBL7287748 | 0.76 | NPBWR1 (0.52) | NPBWR1MCHR1L3MBTL1NPC1MC4R | |
| SCHEMBL7294695 | 0.74 | NPBWR1 (0.47) | NPBWR1MCHR1L3MBTL1NPC1MC4R | |
| SCHEMBL7289036 | 0.72 | NPBWR1 (0.48) | NPBWR1MCHR1L3MBTL1NPC1HTT | |
| SCHEMBL7289042 | 0.72 | NPBWR1 (0.48) | NPBWR1MCHR1L3MBTL1NPC1HTT | |
| SCHEMBL14355804 | 0.72 | BRD9 (0.51) | L3MBTL1HTTTSHRPOLBKDM4E | |
| SCHEMBL7286545 | 0.71 | NPBWR1 (0.54) | NPBWR1MCHR1L3MBTL1NPC1MC4R | |
| SCHEMBL5160922 | 0.71 | NPBWR1 (0.65) | NPBWR1MCHR1KMT2ALMNAGLA | |
| SCHEMBL7295617 | 0.71 | NPBWR1 (0.54) | NPBWR1MCHR1L3MBTL1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810220-B1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6258953-B1 | Arylacrylamide derivatives | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0810220-A1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER INC. (US) | 1997-12-03 | — | — | EP | disclosed |