Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MC4R | P32245 | 9/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294695 | 0.85 | NPBWR1 (0.47) | NPBWR1MCHR1GAAMC4RHTR1A | |
| SCHEMBL7295239 | 0.79 | NPBWR1 (0.48) | NPBWR1MCHR1GAAMC4RHTR1A | |
| SCHEMBL7294686 | 0.76 | NPBWR1 (0.52) | NPBWR1MCHR1MC4RHTR1ADRD2 | |
| SCHEMBL18781674 | 0.70 | NCF1 (0.58) | HTR1ADRD2DRD4HTR2AHTR2C | |
| SCHEMBL7284552 | 0.66 | HTR2A (0.46) | NPBWR1MCHR1HTR1ADRD2DRD4 | |
| SCHEMBL7296105 | 0.66 | NPBWR1 (0.45) | NPBWR1MCHR1GAAHTR1ADRD2 | |
| SCHEMBL7295548 | 0.66 | L3MBTL1 (0.43) | NPBWR1MCHR1GAAHTR1ADRD2 | |
| SCHEMBL7293003 | 0.65 | SMN1; SMN2 (0.45) | NPBWR1MCHR1GAADRD2DRD4 | |
| SCHEMBL5160922 | 0.65 | NPBWR1 (0.65) | NPBWR1MCHR1GAALMNAGLA | |
| SCHEMBL414567 | 0.64 | NCF1 (0.58) | HTR1ADRD2DRD4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258953-B1 | Arylacrylamide derivatives | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0810220-A1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER INC. (US) | 1997-12-03 | — | — | EP | disclosed |