Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295549 | 0.99 | GPR119 (0.42) | GPR119PDE3BPDE3A | |
| SCHEMBL7302859 | 0.89 | GPR119 (0.41) | GPR119PDE3BPDE3A | |
| SCHEMBL7305172 | 0.88 | GPR119 (0.41) | GPR119PDE3BPDE3A | |
| SCHEMBL7304449 | 0.82 | PDE3B (0.39) | GPR119PDE3BPDE3A | |
| SCHEMBL7328370 | 0.81 | HRH3 (0.47) | — | |
| SCHEMBL9687447 | 0.81 | MAPK1 (0.41) | GPR119PDE3BPDE3A | |
| SCHEMBL7295661 | 0.80 | GPR119 (0.41) | GPR119PDE3BPDE3A | |
| SCHEMBL7329284 | 0.80 | GPR119 (0.45) | GPR119 | |
| SCHEMBL7295544 | 0.79 | GPR119 (0.41) | GPR119PDE3BPDE3A | |
| SCHEMBL11356530 | 0.77 | GPR119 (0.49) | GPR119PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |