Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304449 | 0.96 | PDE3B (0.39) | MAPK1SMN1; SMN2GAAMAPTHTT | |
| SCHEMBL7305054 | 0.89 | SLC22A1 (0.39) | SMN1; SMN2MAPTPDE3BPDE3AADRB2 | |
| SCHEMBL7303996 | 0.89 | CTSS (0.43) | ADRB2GPR119ADRB1CYP1A2ADRB3 | |
| SCHEMBL7304427 | 0.88 | ADRB2 (0.43) | MAPTADRB2GPR119ADRB1CYP1A2 | |
| SCHEMBL7306521 | 0.87 | ADRB1 (0.46) | PDE3BPDE3AADRB2GPR119ADRB1 | |
| SCHEMBL9687154 | 0.86 | GPR119 (0.35) | SMN1; SMN2MAPTPDE3BPDE3AGPR119 | |
| SCHEMBL9687213 | 0.85 | MAPK1 (0.44) | MAPK1SMN1; SMN2GAAMAPTHTT | |
| SCHEMBL7305060 | 0.83 | PDE3B (0.43) | SMN1; SMN2MAPTPDE3BPDE3AADRB2 | |
| SCHEMBL7304010 | 0.83 | PDE3B (0.43) | PDE3BPDE3AADRB2GPR119ADRB1 | |
| SCHEMBL7329284 | 0.82 | GPR119 (0.45) | MAPK1SMN1; SMN2GAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |