Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | SCN1A | P35498 | 2/20 | 0.43 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329284 | 0.92 | GPR119 (0.45) | HTR1ASMN1; SMN2MAPTADRB2ADRB1 | |
| SCHEMBL7299789 | 0.86 | ADRB1 (0.49) | HRH3HTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL7305182 | 0.86 | HRH3 (0.46) | HRH3HTR1ASMN1; SMN2MAPTADRB2 | |
| SCHEMBL7335463 | 0.86 | HRH3 (0.54) | HRH3SMN1; SMN2MAPTADRB2ADRB1 | |
| SCHEMBL7306614 | 0.84 | ADRB1 (0.52) | HRH3HTR1ASMN1; SMN2MAPTADRB2 | |
| SCHEMBL9686104 | 0.83 | HRH3 (0.43) | HRH3HTR1ASMN1; SMN2MAPTADRB2 | |
| SCHEMBL9687447 | 0.82 | MAPK1 (0.41) | HTR1ASMN1; SMN2MAPTADRB2ADRB1 | |
| SCHEMBL7304714 | 0.82 | HRH3 (0.46) | HRH3SMN1; SMN2MAPTADRB2ADRB1 | |
| SCHEMBL7295668 | 0.81 | GPR119 (0.42) | — | |
| SCHEMBL7304449 | 0.81 | PDE3B (0.39) | HTR1ASMN1; SMN2MAPTADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |