Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105690 | 0.89 | ESR1 (0.52) | CA2CAMK2AFNTAFNTBESR1 | |
| SCHEMBL31422585 | 0.83 | FFAR1 (0.63) | CA2FFAR1 | |
| Parahydroxybenzyl Alcohol SCHEMBL27626310 | 0.80 | CA2 (0.58) | CA2CAMK2ACYP1A1FNTAFNTB | |
| SCHEMBL21960079 | 0.77 | TOP1 (0.73) | CA2CAMK2AESR1ALDH1A1CYP3A4 | |
| Phenylacetaldehyde SCHEMBL27573996 | 0.77 | CA1 (0.52) | CA2FNTAFNTBTOP1 | |
| SCHEMBL3115195 | 0.77 | CA2 (0.60) | CA2CAMK2AALDH1A1FFAR1 | |
| Hydroxyphenyl Propionic Acid SCHEMBL35486 | 0.77 | FFAR1 (0.68) | CA2CAMK2AESR1ESR2ALDH1A1 | |
| Isobutyraldehyde SCHEMBL3923146 | 0.77 | TAAR1 (0.45) | CA2CAMK2AESR1ESR2 | |
| SCHEMBL2028391 | 0.77 | CA2 (0.65) | CA2CAMK2ACYP1A1FNTAFNTB | |
| SCHEMBL4383010 | 0.77 | ESR1 (0.58) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361310-A2 | BIOSYNTHESIS OF COMMODITY CHEMICALS | Bio Architecture Lab, Inc. (US) | 2011-08-31 | — | — | EP | claimed |
| US-20100185017-A1 | BIOSYNTHESIS OF COMMODITY CHEMICALS | BIO ARCHITECTURE LAB, INC. | 2010-07-22 | — | — | US | claimed |
| WO-2010068921-A2 | BIOSYNTHESIS OF COMMODITY CHEMICALS | BIO ARCHITECTURE LAB, INC. (US) | 2010-06-17 | — | — | WO | claimed |
| EP-2195440-A2 | BIOFUEL PRODUCTION | Bio Architecture Lab, Inc. (US) | 2010-06-16 | — | — | EP | claimed |
| US-20090155873-A1 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-06-18 | — | — | US | claimed |
| US-20090139134-A1 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-06-04 | — | — | US | claimed |
| WO-2009046375-A2 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046370-A2 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-04-09 | — | — | WO | claimed |
| US-20130252312-A1 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-8318464-B2 | Biofuel production | BIO ARCHITECTURE LAB, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-8318473-B2 | Biofuel production | BIO ARCHITECTURE LAB, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-8211689-B2 | Biofuel production | BIO ARCHITECTURE LAB, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| US-8198056-B2 | Biofuel production | BIO ARCHITECTURE LAB, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-20120142081-A1 | BIOSYNTHESIS OF COMMODITY CHEMICALS | BIO ARCHITECTURE LAB, INC. (US) | 2012-06-07 | — | — | US | disclosed |
| WO-2010068921-A2 | BIOSYNTHESIS OF COMMODITY CHEMICALS | BIO ARCHITECTURE LAB, INC. (US) | 2010-06-17 | — | — | WO | disclosed |
| EP-2195440-A2 | BIOFUEL PRODUCTION | Bio Architecture Lab, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| US-20090155873-A1 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090139134-A1 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| WO-2009046375-A2 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046370-A2 | BIOFUEL PRODUCTION | BIO ARCHITECTURE LAB, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100185017-A1 | BIOSYNTHESIS OF COMMODITY CHEMICALS | COASY, HSD17B14, FASN | CA2 3762/4885CAMK2A 3733/4885CYP1A1 63/4885 |
| US-20090139134-A1 | BIOFUEL PRODUCTION | MGAM, DCXR, MANBA | CA2 3146/4885CAMK2A 4018/4885CYP1A1 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.