Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289168 | 0.91 | CES2 (0.33) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL7288991 | 0.91 | GABRP (0.40) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL10560167 | 0.81 | CES2 (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7297596 | 0.81 | MAPT (0.38) | GAAMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL9866843 | 0.80 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL10558285 | 0.80 | GABRP (0.42) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL10557783 | 0.80 | GAA (0.35) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL10558290 | 0.80 | GABRP (0.42) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL10562596 | 0.77 | CES2 (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL9191920 | 0.77 | GRM5 (0.36) | GAAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281045-B1 | BENZOTHIEPINO (5,4-C) PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |