Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953327 | 0.91 | MEN1 (0.62) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL30066521 | 0.88 | ALDH1A1 (0.50) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL30058773 | 0.87 | SMN1; SMN2 (0.49) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL7658562 | 0.86 | L3MBTL1 (0.68) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL30135958 | 0.86 | SMN1; SMN2 (0.54) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL4814264 | 0.86 | MEN1 (0.76) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL3970912 | 0.86 | MEN1 (0.76) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL7393652 | 0.86 | MEN1 (0.76) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL379160 | 0.86 | MEN1 (0.76) | L3MBTL1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL317705 | 0.86 | ADORA3 (0.57) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300726-B1 | PIPERAZINYL DERIVATES OF PURINES AND ISOSTERES THEREOF AS HYPOGLYCEMIC AGENTS | MERCK & CO. INC. (US) | 1993-09-22 | — | — | EP | disclosed |
| US-5057517-A | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents | MERCK & CO., INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0300726-A1 | Piperazinyl derivates of purines and isosteres thereof as hypoglycemic agents | MERCK & CO. INC. (US) | 1989-01-25 | — | — | EP | disclosed |