Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.83 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MGAM | O43451 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SI | P14410 | 2/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29862913 | 1.00 | MAPT (0.83) | MAPTTP53MGAMGAASI | |
| SCHEMBL19973935 | 0.80 | MGAM (0.65) | MAPTTP53MGAMGAASI | |
| SCHEMBL10835010 | 0.80 | MAPT (0.60) | MAPTTP53MGAMGAASI | |
| SCHEMBL8592636 | 0.80 | MAPT (0.65) | MAPTTP53MGAMGAASI | |
| SCHEMBL29885627 | 0.80 | MAPT (0.65) | MAPTTP53MGAMGAASI | |
| SCHEMBL31232976 | 0.78 | MGAM (0.66) | MAPTTP53MGAMGAASI | |
| SCHEMBL18662732 | 0.74 | MGAM (1.00) | MAPTMGAMGAASIMGAM2 | |
| SCHEMBL18662735 | 0.74 | MGAM (1.00) | MAPTMGAMGAASIMGAM2 | |
| SCHEMBL30040360 | 0.73 | MAPT (0.69) | MAPTTP53MGAMGAASI | |
| SCHEMBL3343111 | 0.73 | MAPT (0.69) | MAPTTP53MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210024499-A1 | OXIDIZED BIS(3-INDOLYL)METHANES AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2021-01-28 | — | — | US | disclosed |
| US-20210024499-A1 | OXIDIZED BIS(3-INDOLYL)METHANES AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2021-01-28 | — | — | US | disclosed |
| WO-2019183527-A1 | OXIDIZED BIS(3-INDOLYL)METHANES AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-09-26 | — | — | WO | disclosed |
| CN-103880728-B | A kind of method preparing di-indole methyl hydride compounds | TAIZHOU UNIVERSITY (CN) | 2016-03-30 | — | — | CN | disclosed |
| CN-103880728-A | Method for preparing diindolylmethane compound | UNIV TAIZHOU | 2014-06-25 | — | — | CN | disclosed |
| EP-0991645-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000381-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 1999-01-07 | — | — | WO | disclosed |
| EP-0887348-A1 | Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them | Boehringer Mannheim Italia S.p.A. (IT) | 1998-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024499-A1 | OXIDIZED BIS(3-INDOLYL)METHANES AND USES THEREOF | BCL2, BCOR, BCLAF1 | MAPT 3536/4885TP53 223/4885MGAM 4742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.