Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 11/20 | 0.47 |
| ▸ | EDNRA | P25101 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305832 | 0.91 | ALDH1A1 (0.44) | DHPSEDNRA | |
| SCHEMBL7302917 | 0.90 | EDNRA (0.51) | DHPSEDNRAEDNRB | |
| SCHEMBL7297143 | 0.89 | DHPS (0.42) | DHPSEDNRAMCL1 | |
| SCHEMBL7305025 | 0.88 | DHPS (0.42) | DHPSEDNRAMCL1 | |
| SCHEMBL7293765 | 0.88 | EDNRA (0.44) | DHPSEDNRAHTT | |
| SCHEMBL7300166 | 0.87 | DHPS (0.38) | DHPSEDNRAEDNRB | |
| SCHEMBL8322432 | 0.87 | LMNA (0.41) | DHPSEDNRAHTTMCL1POLB | |
| SCHEMBL7868576 | 0.86 | DHPS (0.51) | DHPSEDNRAHTTMCL1POLB | |
| SCHEMBL7302684 | 0.85 | DHPS (0.38) | DHPSEDNRA | |
| SCHEMBL7292782 | 0.85 | EDNRA (0.40) | DHPSEDNRAHTTMCL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |