Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.64 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.56 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.56 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 10/20 | 0.55 |
| ▸ | MMP9 | P14780 | 10/20 | 0.55 |
| ▸ | MMP8 | P22894 | 3/20 | 0.55 |
| ▸ | MMP12 | P39900 | 2/20 | 0.55 |
| ▸ | MMP14 | P50281 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310154 | 0.87 | MMP2 (0.71) | MMP7SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL31086814 | 0.87 | MMP2 (0.71) | MMP7SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL5189194 | 0.87 | MMP2 (0.71) | MMP7SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL7290941 | 0.87 | MMP2 (0.71) | MMP7SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL8993739 | 0.86 | MMP9 (0.71) | SLC1A3SLC1A2SLC1A1MMP2MMP9 | |
| SCHEMBL8622042 | 0.86 | MMP9 (0.71) | SLC1A3SLC1A2SLC1A1MMP2MMP9 | |
| SCHEMBL8146180 | 0.85 | ALDH1A1 (0.63) | MMP7MMP2MMP9MMP8MMP12 | |
| SCHEMBL8707457 | 0.85 | ALDH1A1 (0.63) | MMP7MMP2MMP9MMP8MMP12 | |
| SCHEMBL8146178 | 0.85 | ALDH1A1 (0.63) | MMP7MMP2MMP9MMP8MMP12 | |
| SCHEMBL6434896 | 0.84 | SLC1A3 (0.61) | SLC1A3SLC1A2SLC1A1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763436-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5595999-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5583133-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5532232-A | INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD | HOFFMANN-LA ROCHE INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0468231-B1 | Guanidins | HOFFMANN LA ROCHE (CH) | 1994-09-21 | — | — | EP | disclosed |
| US-5260307-A | Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma | HOFMANN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0468231-A2 | Guanidins | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-29 | — | — | EP | disclosed |