Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3154669 | 0.82 | CYP2D6 (0.58) | CYP3A4CYP2D6CYP2C9CYP19A1SERPINE1 | |
| SCHEMBL7302933 | 0.81 | MAOB (0.66) | MAOBNAAA | |
| SCHEMBL8923501 | 0.80 | SCN8A (0.49) | CYP3A4CYP2D6CYP2C9CYP19A1SERPINE1 | |
| SCHEMBL23291337 | 0.79 | CHRNA7 (0.65) | CYP3A4CYP2D6CYP2C9CYP19A1SERPINE1 | |
| SCHEMBL30428139 | 0.79 | CHRNA7 (0.65) | CYP3A4CYP2D6CYP2C9CYP19A1SERPINE1 | |
| SCHEMBL11542731 | 0.78 | TDP1 (0.66) | CYP3A4CYP2D6CYP2C9CYP19A1SERPINE1 | |
| SCHEMBL7294953 | 0.77 | GAA (0.56) | CYP3A4CYP2D6CYP2C9SERPINE1CYP2A6 | |
| SCHEMBL6061937 | 0.76 | MAOB (0.64) | MAOBNAAA | |
| SCHEMBL3366231 | 0.76 | CA2 (0.59) | CYP3A4CYP2D6CYP2C9SERPINE1CYP2A6 | |
| SCHEMBL8484229 | 0.76 | ALDH1A1 (0.51) | CYP19A1CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0504574-B1 | 1,2,4-Oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity and method for preparing same | WAKAMOTO PHARMA CO LTD (JP) | 1996-02-28 | — | — | EP | disclosed |
| US-5356916-A | Treating Parkinson*s disease | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| EP-0504574-A1 | 1,2,4-Oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity and method for preparing same | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-23 | — | — | EP | disclosed |