Calycosin

Calycosin

SCHEMBL73013

COc1ccc(-c2coc3cc(O)ccc3c2=O)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 1.00
RAB9A P51151 7/20 1.00
MAPT P10636 6/20 1.00
NPC1 O15118 6/20 1.00
POLB P06746 2/20 1.00
HMGB1 P09429 1/20 1.00
HSD17B10 Q99714 8/20 0.84
TP53 P04637 3/20 0.84
MAPK1 P28482 1/20 0.84
PPARG P37231 4/20 0.77
PTPN1 P18031 1/20 0.77
XDH P47989 2/20 0.72
MIF P14174 1/20 0.72
ALDH1A1 P00352 8/20 0.71
HPGD P15428 7/20 0.71
SMN1; SMN2 Q16637 5/20 0.71
CYP3A4 P08684 4/20 0.71
HDAC6 Q9UBN7 3/20 0.71
CYP2D6 P10635 2/20 0.71
CYP2C9 P11712 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Calycosin SCHEMBL30335127 1.00 KDM4E (1.00) KDM4ERAB9AMAPTNPC1POLB
Cladrin SCHEMBL738092 0.91 KDM4E (1.00) KDM4ERAB9AMAPTNPC1POLB
SCHEMBL2069826 0.90 KDM4E (0.84) KDM4ERAB9AMAPTNPC1POLB
SCHEMBL29788255 0.90 KDM4E (0.84) KDM4ERAB9AMAPTNPC1POLB
SCHEMBL10441842 0.89 KDM4E (0.80) KDM4ERAB9AMAPTNPC1POLB
Glycitein SCHEMBL5483545 0.88 HDAC6 (0.91) KDM4ERAB9AMAPTNPC1POLB
SCHEMBL28124530 0.88 KDM4E (0.80) KDM4ERAB9AMAPTNPC1POLB
Odoratin SCHEMBL1248967 0.87 PTPN1 (1.00) KDM4ERAB9AMAPTNPC1POLB
SCHEMBL29929620 0.87 KDM4E (0.77) KDM4ERAB9AMAPTNPC1POLB
SCHEMBL2491956 0.86 MAPT (0.76) KDM4ERAB9AMAPTNPC1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1446 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122084809-A Feature map detection method of detumescence particles or intermediate extract thereof and application thereof 2026-05-26 CN claimed
CN-117327135-B Method for increasing leaching of saccharides and glycoside components and application thereof INSTITUTE OF CHINESE MATERIA MEDICA, CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) 2026-05-26 CN claimed
CN-120939042-B Application of cajanin, cordyceps polysaccharide or calycosin in combination in preparation of medicine for relieving toxic injury of vomitoxin 吉林大学 2026-05-19 CN claimed
CN-122031494-A Application of calycosin glycoside in preparation of medicines for relieving ulcerative colitis 黄冈师范学院 2026-05-15 CN claimed
CN-119732967-B Application of astragalus-curcuma zedoary medicine pair active ingredient composition in preparation of anti-tumor metastasis medicines 中国药科大学 2026-05-15 CN claimed
CN-122031598-A Preparation method and application of nephritis medicine 五源本草(山东)健康科技有限公司 2026-05-15 CN claimed
CN-122005706-A Qishenpngji granule for treating ventricular premature beat and quality detection method thereof 江苏省中医院 2026-05-12 CN claimed
CN-121577776-A Fingerprint analysis method of seven-ingredient radix stephaniae tetrandrae and astragalus membranaceus particles 正大青春宝药业有限公司 2026-02-27 CN claimed
EP-3888670-B1 DRUG FOR TREATING LEUKOPENIA, PREPARATION METHOD THEREFOR AND USE THEREOF MONYAN PHARMACEUTICAL CO LTD (CN) 2025-12-24 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
CN-112641916-B Traditional Chinese medicine ointment formula for building body and preparation method thereof 辽宁上药好护士药业(集团)有限公司 2022-02-01 CN claimed
CN-113960184-A Establishment and quality detection method of blood-replenishing and motherwort-tonifying pill fingerprint spectrum 株洲千金药业股份有限公司 2022-01-21 CN claimed
US-10406191-B2 Compounds, extracts and methods from chinese medicinal herb sophora flavescens that inhibit airway contraction Li, Xui-Min (US) 2019-09-10 US claimed
US-20150359834-A1 COMPOUNDS, EXTRACTS AND METHODS FROM CHINESE MEDICINAL HERB SOPHORA FLAVESCENS THAT INHIBIT AIRWAY CONTRACTION LI, XIU-MIN 2015-12-17 US claimed
WO-2014113784-A1 COMPOUNDS, EXTRACTS AND METHODS FROM CHINESE MEDICINAL HERB SOPHORA FLAVESCENS THAT INHIBIT AIRWAY CONTRACTION LI XIU-MIN (US) 2014-07-24 WO claimed
CN-102657641-A Application of calycosin to preparation of medicine for resisting vascular dementia UNIV XINXIANG MEDICAL 2012-09-12 CN claimed
US-20120016019-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER LEE GEE-HWOON (KR) 2012-01-19 US claimed
US-20120016017-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER LEE GEE-HWOON (KR) 2012-01-19 US claimed
US-20120015056-A1 COMPOSITION COMPRISING EXTRACTS OR FRACTIONS OF SPECIFIC PLANTS, USE THEREOF AND PROCESS FOR PREPARING THE EXTRACTS LEE GEE-HWOON (KR) 2012-01-19 US claimed
WO-2012008762-A2 COMPOSITION COMPRISING EXTRACTS OR FRACTIONS OF SPECIFIC PLANTS, USE THEREOF AND PROCESS FOR PREPARING THE EXTRACTS LEE GEE-HWOON (KR) 2012-01-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120016019-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-5, KRAS KDM4E 4070/4885RAB9A 755/4885MAPT 3047/4885
US-20120016017-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, WASHC5, ASAH1 KDM4E 3250/4885RAB9A 663/4885MAPT 3541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.