Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307549 | 0.94 | HTR7 (0.39) | HTR7KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7305724 | 0.94 | DRD3 (0.39) | HTR7KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7298911 | 0.92 | ALDH1A1 (0.40) | HTR7KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7310926 | 0.89 | TP53 (0.41) | KDM4ESIGMAR1DRD3MAPTTDP1 | |
| SCHEMBL7308261 | 0.87 | HTR7 (0.45) | HTR7KDM4ESIGMAR1MAPTPPARG | |
| SCHEMBL7330914 | 0.87 | HTR1A (0.46) | HTR7KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7299417 | 0.84 | KDM4E (0.42) | HTR7KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7310058 | 0.82 | PPARG (0.42) | HTR7KDM4ESIGMAR1DRD3PPARG | |
| SCHEMBL7299031 | 0.82 | HTR1A (0.46) | HTR7KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7299099 | 0.81 | HTR1A (0.48) | KDM4ESIGMAR1DRD3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| CN-1060841-A | Quinazoline derivant and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-05-06 | — | — | CN | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |