Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307549 | 0.94 | HTR7 (0.39) | ALDH1A1KDM4ETDP1ALOX15APEX1 | |
| SCHEMBL7305724 | 0.94 | DRD3 (0.39) | ALDH1A1KDM4ETDP1ALOX15APEX1 | |
| SCHEMBL7301366 | 0.89 | HTR7 (0.41) | ALDH1A1KDM4ETDP1ALOX15APEX1 | |
| SCHEMBL7298911 | 0.88 | ALDH1A1 (0.40) | TP53HTTALDH1A1KDM4ETDP1 | |
| SCHEMBL7295815 | 0.86 | PPARG (0.44) | ALDH1A1KDM4ETDP1ALOX15APEX1 | |
| SCHEMBL7305222 | 0.86 | HTR1A (0.47) | ALDH1A1KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7301695 | 0.84 | KDM4E (0.44) | ALDH1A1KDM4ETDP1ALOX15APEX1 | |
| SCHEMBL7303017 | 0.83 | SIGMAR1 (0.39) | ALDH1A1KDM4ETDP1ALOX15APEX1 | |
| SCHEMBL7299099 | 0.82 | HTR1A (0.48) | ALDH1A1KDM4ESIGMAR1DRD3MAPT | |
| SCHEMBL7365452 | 0.81 | PPARG (0.43) | SIGMAR1DRD3PPARGPPARAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |