Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | IL1RN | P18510 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306530 | 0.81 | LNPEP (0.45) | KDM5BMAPTGSK3BIL1RNNPC1 | |
| Lithium Ion SCHEMBL7297039 | 0.76 | KDM4A (0.41) | KDM5BMAPTGSK3BIL1RNHDAC3 | |
| SCHEMBL7295772 | 0.75 | TACR1 (0.54) | HDAC8 | |
| SCHEMBL7303694 | 0.75 | LNPEP (0.57) | KDM5BIL1RNNPC1HPGDRAB9A | |
| SCHEMBL9244629 | 0.74 | LNPEP (0.42) | KDM5BMAPTGSK3BIL1RNNPC1 | |
| Hydrochloric Acid SCHEMBL7303882 | 0.74 | LNPEP (0.56) | KDM5BIL1RNNPC1HPGDRAB9A | |
| SCHEMBL7297368 | 0.74 | KDM5A (0.44) | KDM5BMAPTGSK3BMAPK14 | |
| SCHEMBL7300179 | 0.74 | KDM5B (0.45) | KDM5BMAPTGSK3BNPC1HPGD | |
| SCHEMBL7297463 | 0.73 | BTN3A1 (0.42) | MAPTSMN1; SMN2 | |
| SCHEMBL7303824 | 0.72 | LNPEP (0.43) | KDM5BMAPTGSK3BIL1RNGPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |