Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303824 | 0.91 | LNPEP (0.43) | LNPEPKDM5BIL1RNMAPTGSK3B | |
| SCHEMBL7295772 | 0.82 | TACR1 (0.54) | ALDH1A1 | |
| SCHEMBL9244629 | 0.82 | LNPEP (0.42) | LNPEPKDM5BIL1RNHPGDLMNA | |
| SCHEMBL7301392 | 0.81 | KDM5B (0.42) | LNPEPKDM5BIL1RNHPGDMAPT | |
| SCHEMBL7303694 | 0.80 | LNPEP (0.57) | LNPEPKDM5BIL1RNHPGDERAP2 | |
| Hydrochloric Acid SCHEMBL7303882 | 0.79 | LNPEP (0.56) | LNPEPKDM5BIL1RNHPGDERAP2 | |
| SCHEMBL7300179 | 0.79 | KDM5B (0.45) | LNPEPKDM5BHPGDMAPTGSK3B | |
| SCHEMBL7297368 | 0.77 | KDM5A (0.44) | KDM5BMAPTGSK3BALDH1A1 | |
| SCHEMBL9138312 | 0.74 | CTSK (0.47) | MAPTALDH1A1TSHR | |
| SCHEMBL10779210 | 0.73 | CYP1A2 (0.49) | LNPEPKDM5BHPGDALDH1A1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |