Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297442 | 0.97 | SIGMAR1 (0.51) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9686839 | 0.94 | DRD2 (0.47) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7298072 | 0.94 | DRD2 (0.47) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7299433 | 0.92 | DRD2 (0.46) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7333026 | 0.92 | ADRB1 (0.41) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7331185 | 0.90 | DRD2 (0.49) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7331550 | 0.90 | DRD2 (0.49) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7306634 | 0.89 | DRD2 (0.48) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL4621588 | 0.88 | ADRB1 (0.43) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9686027 | 0.85 | ADRB1 (0.40) | SIGMAR1DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |