Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298072 | 0.97 | DRD2 (0.47) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7331550 | 0.97 | DRD2 (0.49) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7299433 | 0.95 | DRD2 (0.46) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7301723 | 0.94 | SIGMAR1 (0.49) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7331185 | 0.94 | DRD2 (0.49) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7306634 | 0.92 | DRD2 (0.48) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL9686027 | 0.92 | ADRB1 (0.40) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7297442 | 0.90 | SIGMAR1 (0.51) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7303810 | 0.89 | ADRB1 (0.40) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7303225 | 0.89 | ADRB1 (0.41) | DRD2HTR2AHTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |