SCHEMBL7302157

SCHEMBL7302157

O=C(O)C1CCCN(C(=O)c2cccnc2)C1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.62
HTT P42858 3/20 0.62
KDM4E B2RXH2 1/20 0.62
KLK7 P49862 1/20 0.61
RXFP1 Q9HBX9 1/20 0.61
PKM P14618 1/20 0.58
VNN1 O95497 1/20 0.53
CHRNB2 P17787 1/20 0.53
CHRNB4 P30926 1/20 0.53
CHRNA3 P32297 1/20 0.53
CHRNA7 P36544 1/20 0.53
CHRNA4 P43681 1/20 0.53
MAPT P10636 2/20 0.52
GAA P10253 1/20 0.52
SLC18A3 Q16572 1/20 0.51
PDE2A O00408 1/20 0.51
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
GRM3 Q14832 1/20 0.50
LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5908875 0.88 VNN1 (0.67) ALDH1A1HTTKDM4EKLK7RXFP1
SCHEMBL21926498 0.87 KLK7 (0.64) ALDH1A1HTTKDM4EKLK7RXFP1
SCHEMBL16442058 0.84 ALDH1A1 (0.64) ALDH1A1KDM4EGRM3
SCHEMBL1520334 0.84 ALDH1A1 (0.64) ALDH1A1KDM4EGRM3
SCHEMBL7232912 0.84 ALDH1A1 (0.64) ALDH1A1KDM4EGRM3
SCHEMBL31700370 0.84 VNN1 (0.66) ALDH1A1HTTKDM4EKLK7RXFP1
SCHEMBL13211802 0.83 RECQL (0.72) ALDH1A1HTTKDM4EKLK7RXFP1
SCHEMBL8255072 0.83 ALDH1A1 (0.54) ALDH1A1HTTKDM4EKLK7RXFP1
SCHEMBL1553823 0.82 RHOA (0.55) ALDH1A1HTTKDM4EKLK7RXFP1
SCHEMBL15646173 0.82 KLK7 (0.58) ALDH1A1HTTKDM4EKLK7RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0520336-A2 Aldehyde derivatives and their use as calpain inhibitors FUJIREBIO Inc. (JP) 1992-12-30 EP disclosed