Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302297 | 0.84 | MEN1 (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL27989783 | 0.74 | MEN1 (0.71) | MEN1KMT2AALDH1A1SMN1; SMN2STS | |
| SCHEMBL6790862 | 0.72 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6785770 | 0.70 | POLB (0.38) | ALDH1A1GAAMAPTGPR119LMNA | |
| SCHEMBL557597 | 0.70 | DRD2 (0.61) | MEN1KMT2AALDH1A1SMN1; SMN2STS | |
| SCHEMBL8425470 | 0.70 | MEN1 (0.42) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1001982 | 0.69 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2STSHTT | |
| SCHEMBL31117881 | 0.69 | MEN1 (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2STS | |
| SCHEMBL7367231 | 0.69 | MMP13 (0.55) | MEN1KMT2ASTSGPR119 | |
| SCHEMBL23329451 | 0.69 | RORC (0.43) | MEN1KMT2AALDH1A1MAPTGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |