Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506409 | 0.73 | KDM4E (0.33) | NOTUMGAAKDM4EHPGD | |
| SCHEMBL7302420 | 0.70 | GAA (0.46) | NOTUMGAA | |
| SCHEMBL10705745 | 0.62 | KMT2A (0.47) | NOTUMFAAHGAAKDM4EHPGD | |
| SCHEMBL12377823 | 0.61 | NOTUM (0.49) | NOTUMFAAHKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12128212 | 0.59 | ALDH1A1 (0.52) | GAAKDM4E | |
| SCHEMBL9737564 | 0.58 | RAB9A (0.58) | HPGDKMT2ASMN1; SMN2ESR2ESR1 | |
| SCHEMBL9422430 | 0.58 | CA1 (0.65) | GAAKDM4EHPGDSMN1; SMN2ESR2 | |
| SCHEMBL23451693 | 0.57 | NOTUM (1.00) | NOTUMKDM4EHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL18121825 | 0.57 | NOTUM (0.70) | NOTUMGAAKDM4EHPGDKMT2A | |
| SCHEMBL11857867 | 0.56 | FAAH (0.46) | FAAHESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525619-A | INHIBITORS OF MONOAMINE OXIDASE B | SYNTHELABO (FR) | 1996-06-11 | — | — | US | disclosed |
| EP-0655445-A1 | 1,3,4-oxadiazol-2(3H)-one Derivates, their preparation and their use as monoamine oxidase inhibitors | SYNTHELABO (FR) | 1995-05-31 | — | — | EP | disclosed |