Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.44 |
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10441294 | 0.88 | ACACB (0.45) | ACACBPPARAPPARGCTSLCTSK | |
| SCHEMBL12728270 | 0.88 | ACACB (0.45) | ACACBPPARAPPARGCTSLCTSK | |
| SCHEMBL16542991 | 0.82 | EPHX2 (0.37) | ACACBPPARAEPHX2PPARGLDHA | |
| SCHEMBL7882113 | 0.81 | MMP8 (0.51) | EPHX2PPARGTSHRKMT2AMMP8 | |
| SCHEMBL279730 | 0.81 | MMP8 (0.51) | EPHX2PPARGTSHRKMT2AMMP8 | |
| SCHEMBL9493601 | 0.79 | MMP8 (0.49) | ACACBPPARAEPHX2PPARGOPRK1 | |
| SCHEMBL7321751 | 0.77 | ACACB (0.49) | ACACBPPARAEPHX2PPARGOPRK1 | |
| SCHEMBL4451910 | 0.76 | PPARA (0.51) | ACACBPPARAEPHX2PPARGOPRK1 | |
| SCHEMBL23280984 | 0.76 | MEN1 (0.43) | ACACBPPARAPPARGKMT2A | |
| SCHEMBL15729872 | 0.75 | LDHA (0.53) | ACACBPPARAPPARGLDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358398-B1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | disclosed |
| EP-0358398-A1 | Cycloalkyl-substituted glutaramide antihypertensive agents | Pfizer Limited (GB) | 1990-03-14 | — | — | EP | disclosed |