Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 2/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16633434 | 0.86 | EPHX2 (0.58) | MMP8ACACBLDHAPPARAPPARG | |
| SCHEMBL7321751 | 0.85 | ACACB (0.49) | MMP8ACACBLDHAPPARAPPARG | |
| SCHEMBL1312803 | 0.85 | MMP8 (0.62) | MMP8LDHAPPARGEPHX2TSHR | |
| SCHEMBL4451910 | 0.84 | PPARA (0.51) | ACACBPPARAPPARGEPHX2ABCB11 | |
| SCHEMBL490486 | 0.82 | LDHA (0.69) | MMP8LDHAPPARAPPARGEPHX2 | |
| SCHEMBL5752813 | 0.81 | SLC6A2 (0.42) | MMP8PPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL6377515 | 0.81 | MMP8 (0.51) | MMP8ACACBLDHAPPARGEPHX2 | |
| SCHEMBL6711568 | 0.80 | MMP8 (0.57) | MMP8LDHAPPARAPPARGTSHR | |
| SCHEMBL7302776 | 0.79 | ACACB (0.44) | MMP8ACACBLDHAPPARAPPARG | |
| SCHEMBL2574253 | 0.79 | EPHX2 (0.54) | MMP8ACACBLDHAPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254080-B1 | MALONIC ACID DERIVATIVES AND METHODS FOR THEIR SYNTHESIS | ENIRICERCHE S.p.A. (IT) | 1993-03-17 | — | — | EP | disclosed |
| US-4914226-A | Malonic acid derivatives and methods for their synthesis | ENIRICERCHE S.P.A. (IT) | 1990-04-03 | — | — | US | disclosed |
| EP-0254080-A2 | Malonic acid derivatives and methods for their synthesis | ENIRICERCHE S.p.A. (IT) | 1988-01-27 | — | — | EP | disclosed |