Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 6/20 | 0.48 |
| ▸ | CES2 | O00748 | 4/20 | 0.45 |
| ▸ | FDPS | P14324 | 9/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121043 | 1.00 | GGPS1 (0.48) | GGPS1CES2FDPSCYP4F2CYP4A11 | |
| SCHEMBL8848020 | 0.98 | GGPS1 (0.45) | GGPS1CES2FDPSCYP4F2CYP4A11 | |
| SCHEMBL8847814 | 0.91 | GGPS1 (0.37) | GGPS1CES2FDPSCYP4F2CYP4A11 | |
| SCHEMBL8943570 | 0.82 | GGPS1 (0.48) | GGPS1CES2FDPSCES1 | |
| SCHEMBL277241 | 0.80 | — | — | |
| SCHEMBL2340809 | 0.79 | CES2 (0.47) | GGPS1CES2FDPSCYP4F2CYP4A11 | |
| SCHEMBL2351092 | 0.79 | FDPS (0.47) | GGPS1CES2FDPS | |
| SCHEMBL11048015 | 0.79 | ACLY (0.63) | CES2 | |
| SCHEMBL284791 | 0.79 | ACLY (0.63) | CES2 | |
| SCHEMBL1716734 | 0.79 | ACLY (0.63) | CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0502314-A1 | Benzimidazol, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-09 | — | — | EP | disclosed |