Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302158 | 0.87 | SLC6A3 (0.46) | KMT2ANPC1MEN1KDM4EPOLB | |
| SCHEMBL9318361 | 0.86 | AR (0.38) | ARKMT2ANPC1MEN1KDM4E | |
| SCHEMBL7303338 | 0.85 | AR (0.34) | ARKMT2ANPC1MEN1RAB9A | |
| SCHEMBL7302852 | 0.85 | KDM4E (0.44) | ARKMT2ANPC1MEN1KDM4E | |
| SCHEMBL9309854 | 0.85 | TSHR (0.47) | KMT2ANPC1MEN1KDM4ERAB9A | |
| SCHEMBL7312950 | 0.83 | KDM4E (0.53) | KMT2ANPC1MEN1KDM4EPOLB | |
| SCHEMBL7303042 | 0.81 | NPC1 (0.47) | KMT2ANPC1MEN1POLBRAB9A | |
| SCHEMBL9318354 | 0.79 | KDM4E (0.45) | ARKMT2ANPC1MEN1KDM4E | |
| SCHEMBL9318344 | 0.73 | CYP4F2 (0.36) | ARKMT2ASLC6A3HTTALOX5 | |
| SCHEMBL9313945 | 0.73 | CYP4F2 (0.48) | KMT2AMEN1KDM4ERAB9AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514198-B1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LTD (GB) | 1998-08-05 | — | — | EP | disclosed |
| US-5498722-A | HYPOTENSIVES | GLAXO GROUP (GB) | 1996-03-12 | — | — | US | disclosed |
| US-5332831-A | Angiotensin antagonist | GLAXO GROUP LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| US-5317023-A | 2-Phenyl-(imidazo(4,5-b)pyridyl-methyl-) derivatives; hypertensive agents; cognition activators | GLAXO GROUP LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| US-5310927-A | Hypotensive agents; cognition activators; imidazolyl-2-aryl derivatives | GLAXO GROUP LIMITED (GB) | 1994-05-10 | — | — | US | disclosed |
| CN-1079223-A | Benzofuran derivative | GLAXO GROUP LTD (GB) | 1993-12-08 | — | — | CN | disclosed |
| US-5252593-A | Hypotensive agents, cognition activators | GLAXO GROUP LIMITED (GB) | 1993-10-12 | — | — | US | disclosed |
| WO-1992020679-A1 | BENZOFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514197-A1 | Anti-hypertensive benzofuran derivatives substituted by N-imidazolyl-methyl groups which are condensed with optionally nitrogen containing, six-membered rings | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| EP-0514217-A1 | Antihypertensive benzofuran derivatives carrying 4-pyrazolylmethyl substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| EP-0514193-A1 | N-linked imidazolyl-methyl benzofuran derivatives with antihypotensive activity | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| EP-0514198-A1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |