Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309854 | 0.89 | TSHR (0.47) | NPC1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7314778 | 0.87 | TSHR (0.46) | NPC1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7303033 | 0.86 | NPC1 (0.46) | NPC1MEN1KMT2ADHODHALDH1A1 | |
| SCHEMBL7302158 | 0.84 | SLC6A3 (0.46) | NPC1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7312950 | 0.82 | KDM4E (0.53) | NPC1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7302856 | 0.81 | AR (0.38) | NPC1MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL9313945 | 0.79 | CYP4F2 (0.48) | MEN1KMT2AALDH1A1TSHRRAB9A | |
| SCHEMBL9710721 | 0.74 | ALDH1A1 (0.47) | NPC1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8544448 | 0.74 | KMT2A (0.46) | NPC1KMT2AALDH1A1TSHRRAB9A | |
| SCHEMBL9309848 | 0.74 | ALOX5 (0.53) | NPC1MEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310927-A | Hypotensive agents; cognition activators; imidazolyl-2-aryl derivatives | GLAXO GROUP LIMITED (GB) | 1994-05-10 | — | — | US | disclosed |
| EP-0514193-A1 | N-linked imidazolyl-methyl benzofuran derivatives with antihypotensive activity | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016552-A1 | 1-IMIDAZOLGEMETHYL BENZOFURAN DERIVATIVES AS INHIBITORS OF ANGIOTENSIN II ACTIVITY | GLAXO GROUP LIMITED (GB) | 1992-10-01 | — | — | WO | disclosed |
| EP-0505954-A1 | N-Imidazolylmethyl benzofuran derivatives as inhibitors of angiotensin II activity | GLAXO GROUP LIMITED (GB) | 1992-09-30 | — | — | EP | disclosed |