Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665813 | 0.82 | ALDH1A1 (0.55) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL7295452 | 0.80 | ALDH1A1 (0.42) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL6243896 | 0.76 | ALDH1A1 (0.53) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL6444521 | 0.76 | ALOX5 (0.41) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL6447034 | 0.74 | AOC3 (0.42) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL6709448 | 0.74 | UTS2R (0.41) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL6894430 | 0.73 | ALDH1A1 (0.51) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL1285411 | 0.73 | ALDH1A1 (0.51) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL6897764 | 0.73 | ALDH1A1 (0.51) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 | |
| SCHEMBL9560093 | 0.73 | ALDH1A1 (0.51) | ALDH1A1CYP2C9CYP2C19CYP1A2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0521827-B1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA GEIGY AG (CH) | 1996-09-25 | — | — | EP | disclosed |
| EP-0521827-A1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-01-07 | — | — | EP | disclosed |