Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | HRH1 | P35367 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5597718 | 0.90 | KMT2A (0.71) | HTR1ASLC6A4ALDH1A1KMT2AGFER | |
| SCHEMBL13089443 | 0.90 | ALDH1A1 (0.58) | DRD2HRH1HTR1AHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL4820975 | 0.89 | ALDH1A1 (0.71) | HTR1ASLC6A4ALDH1A1KMT2AGFER | |
| SCHEMBL7755956 | 0.85 | TSHR (0.70) | DRD2HRH1HTR1AHTR2AHTR7 | |
| SCHEMBL7645836 | 0.84 | ALDH1A1 (0.81) | DRD2HRH1HTR1AHTR2AHTR7 | |
| SCHEMBL10603564 | 0.84 | ALDH1A1 (0.81) | DRD2HRH1HTR1AHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL10788566 | 0.84 | TSHR (0.72) | DRD2HRH1HTR1AHTR2ADRD3 | |
| SCHEMBL7388601 | 0.83 | DRD2 (0.63) | DRD2HRH1HTR1AHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL10606849 | 0.83 | ALDH1A1 (0.82) | DRD2HRH1HTR1AHTR2AHTR7 | |
| SCHEMBL501352 | 0.81 | ALDH1A1 (0.82) | DRD2HRH1HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5238934-A | — | — | None | — | — | JP | disclosed |
| EP-0538897-B1 | The use of BMY 14802 in the treatment of anxiety in benzodiazepine-withdrawn patients | BRISTOL MYERS SQUIBB CO (US) | 1997-03-26 | — | — | EP | disclosed |
| US-5278164-A | Treatment of anxiety in benzodiazepine-withdrawn patients | BRISTOL-MYERS SQUIBB CO. (US) | 1994-01-11 | — | — | US | disclosed |
| JP-H05238934-A | ANTIDEPRESSANT | BRISTOL MYERS SQUIBB CO | 1993-09-17 | — | — | JP | disclosed |
| EP-0538897-A1 | The use of BMY 14802 in the treatment of anxiety in benzodiazepine-withdrawn patients | Bristol-Myers Squibb Company (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5055470-A | METHOD OF TREATMENT OF ISCHEMIA IN BRAIN | BRISTOL-MYERS SQUIBB CO. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4994460-A | Treatment or prevention of disorders resulting from central nervous system anoxia | BRISTOL-MYERS SQUIBB CO. (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0410114-A2 | Use of 4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-(4-fluorophenyl)-butanol in pharmaceutical compositions for the treatment of ischemia in brain | Bristol-Myers Squibb Company (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0400661-A1 | Agents for treatment of brain ischemia | Bristol-Myers Squibb Company (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4605655-A | NEUROLEPTIC AGENTS; NO MOVEMENT DISORDER SIDE EFFECTS | BRISTOL-MYERS COMPANY (US) | 1986-08-12 | — | — | US | disclosed |
| US-3933824-A | Piperazinobutyrophenone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-01-20 | — | — | US | disclosed |
| US-3933824-A | Piperazinobutyrophenone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-01-20 | — | — | US | disclosed |
| US-3933824-A | Piperazinobutyrophenone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-01-20 | — | — | US | disclosed |