Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261433 | 0.88 | PSMB5 (0.56) | GAAKMT2APSMB5MAPTALDH1A1 | |
| SCHEMBL9268429 | 0.88 | PSMB5 (0.56) | GAAKMT2APSMB5MAPTALDH1A1 | |
| SCHEMBL7393093 | 0.85 | AKR1B1 (0.55) | KMT2AMAPTMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7326381 | 0.81 | ALDH1A1 (0.58) | GAAKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7297922 | 0.81 | ITGB3 (0.54) | KMT2AMAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL7292044 | 0.81 | HDAC1 (0.51) | KMT2AMAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL7293128 | 0.81 | ITGB3 (0.54) | KMT2AMAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL1252411 | 0.79 | FFAR1 (0.65) | GAAKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2346349 | 0.78 | FFAR1 (0.62) | GAAKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3858000 | 0.77 | CNR1 (0.63) | GAAMAPTALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381033-B1 | Carboxylic-acid and sulphonic-acid amides | HOFFMANN LA ROCHE (CH) | 1994-03-23 | — | — | EP | disclosed |
| EP-0381033-A1 | Carboxylic-acid and sulphonic-acid amides | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-08 | — | — | EP | disclosed |