Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297922 | 1.00 | ITGB3 (0.54) | ITGB3ITGA2BHDAC1MAPTMAPK1 | |
| SCHEMBL9270255 | 0.88 | MEN1 (0.52) | ITGB3ITGA2BHDAC1MAPTMEN1 | |
| SCHEMBL7303533 | 0.88 | MEN1 (0.52) | ITGB3ITGA2BHDAC1MAPTMEN1 | |
| SCHEMBL7292044 | 0.88 | HDAC1 (0.51) | ITGB3ITGA2BHDAC1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL9271864 | 0.87 | MEN1 (0.51) | ITGB3ITGA2BHDAC1MAPTMEN1 | |
| SCHEMBL7493453 | 0.87 | PRSS1 (0.58) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7293149 | 0.86 | ITGB3 (0.55) | ITGB3ITGA2BKMT2AALDH1A1MRGPRX1 | |
| SCHEMBL7302885 | 0.81 | GAA (0.56) | HDAC1MAPTMAPK1MEN1KMT2A | |
| SCHEMBL7122825 | 0.80 | ITGB3 (0.75) | ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL8040370 | 0.79 | ITGB3 (0.73) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381033-B1 | Carboxylic-acid and sulphonic-acid amides | HOFFMANN LA ROCHE (CH) | 1994-03-23 | — | — | EP | claimed |
| US-5256812-A | Antitumor agents, cardiovascular disorders; having amidino or guandino groups | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | claimed |
| EP-0381033-A1 | Carboxylic-acid and sulphonic-acid amides | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-08 | — | — | EP | claimed |
| US-5399585-A | Anitcoagulants, antiinflammatory, antitumor | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0381033-B1 | Carboxylic-acid and sulphonic-acid amides | HOFFMANN LA ROCHE (CH) | 1994-03-23 | — | — | EP | disclosed |
| US-5256812-A | Antitumor agents, cardiovascular disorders; having amidino or guandino groups | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5084466-A | Anticoagulants, antiinflammatory agents, atheriosclerosis and antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1992-01-28 | — | — | US | disclosed |