Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303325 | 0.88 | SIGMAR1 (0.58) | SIGMAR1ALDH1A1TSHRCYP2A13POLB | |
| SCHEMBL7299921 | 0.81 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1TSHRKDM4EACHE | |
| SCHEMBL7303834 | 0.80 | SIGMAR1 (0.77) | SIGMAR1POLBACHECYP11B1CYP11B2 | |
| SCHEMBL7305898 | 0.80 | SIGMAR1 (0.77) | SIGMAR1ALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL8946184 | 0.79 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1POLBKDM4EACHE | |
| SCHEMBL7294524 | 0.79 | SIGMAR1 (0.76) | SIGMAR1ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL17237763 | 0.79 | SIGMAR1 (0.75) | SIGMAR1ALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL7298240 | 0.79 | SIGMAR1 (0.75) | SIGMAR1ALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL7299989 | 0.79 | SIGMAR1 (0.75) | SIGMAR1ALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL7345625 | 0.78 | SIGMAR1 (0.66) | SIGMAR1TDP1MAPK1HTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519023-A | SCHIZOPHRENIA | ADIR ET COMPAGNIE (FR) | 1996-05-21 | — | — | US | claimed |
| US-5519023-A | SCHIZOPHRENIA | ADIR ET COMPAGNIE (FR) | 1996-05-21 | — | — | US | disclosed |
| EP-0580503-B1 | Aminoalkylchromones, process for their preparation and compositions containing them | ADIR (FR) | 1995-06-14 | — | — | EP | disclosed |
| EP-0580503-A1 | Aminoalkylchromones, process for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-01-26 | — | — | EP | disclosed |