Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 3/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSH | P09668 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9439343 | 1.00 | CTSK (0.36) | CTSKCTSSCPB2LTA4HCYP2D6 | |
| SCHEMBL7274874 | 0.87 | CTSS (0.46) | CTSKCTSSREN | |
| SCHEMBL10777312 | 0.87 | CTSS (0.46) | CTSKCTSSREN | |
| SCHEMBL7268415 | 0.82 | CTSK (0.37) | CTSKCTSSCPB2LTA4HREN | |
| SCHEMBL7269844 | 0.80 | CTSK (0.42) | CTSKCTSSLTA4HCTSLCTSB | |
| SCHEMBL7278776 | 0.80 | CTSK (0.42) | CTSKCTSSLTA4HCTSLCTSB | |
| SCHEMBL3565758 | 0.80 | REN (0.39) | CTSKCTSSLTA4HRENMETAP2 | |
| SCHEMBL3565755 | 0.80 | REN (0.39) | CTSKCTSSLTA4HRENMETAP2 | |
| SCHEMBL7295043 | 0.79 | GAA (0.37) | CTSKCTSSRENCTSL | |
| SCHEMBL9439337 | 0.79 | GAA (0.37) | CTSKCTSSRENCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278148-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0389898-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-03 | — | — | EP | disclosed |