Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | CASP7 | P55210 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167600 | 0.89 | TDP1 (0.79) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL26468007 | 0.87 | TDP1 (0.77) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL7168043 | 0.84 | TDP1 (0.72) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL7395072 | 0.82 | MAPK1 (0.74) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL31333098 | 0.81 | TDP1 (1.00) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL230292 | 0.81 | TDP1 (1.00) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL11514743 | 0.81 | TDP1 (0.68) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL4942171 | 0.81 | ALDH1A1 (0.68) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL4057290 | 0.81 | L3MBTL1 (0.68) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 | |
| SCHEMBL4063056 | 0.81 | TDP1 (0.68) | TDP1MAPK1ALDH1A1L3MBTL1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604353-B1 | Benzimidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1998-07-01 | — | — | EP | disclosed |
| US-5441969-A | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1995-08-15 | — | — | US | disclosed |
| EP-0604353-A1 | Benzimidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1994-06-29 | — | — | EP | disclosed |