Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.60 |
| ▸ | TTR | P02766 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MMP1 | P03956 | 5/20 | 0.58 |
| ▸ | FDPS | P14324 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL889739 | 0.92 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2ALOX15HSD17B10 | |
| SCHEMBL14259641 | 0.85 | TDP1 (0.80) | KDM4EALOX15HSD17B10HPGDTP53 | |
| SCHEMBL7627853 | 0.85 | HSD17B10 (0.80) | KDM4EALDH1A1ALOX15HSD17B10HPGD | |
| SCHEMBL30075809 | 0.83 | TP53 (0.60) | KDM4EALDH1A1SMN1; SMN2ALOX15HSD17B10 | |
| SCHEMBL5597077 | 0.82 | SRC (0.75) | KDM4EALDH1A1ALOX15HSD17B10HPGD | |
| SCHEMBL10028945 | 0.82 | SRC (0.75) | KDM4EALDH1A1ALOX15HSD17B10HPGD | |
| Methyl Cis-3,4-Dimethoxycinnamate SCHEMBL2411956 | 0.82 | FDPS (0.80) | KDM4EALDH1A1SMN1; SMN2ALOX15HSD17B10 | |
| Methyl Cis-3,4-Dimethoxycinnamate SCHEMBL2411955 | 0.82 | FDPS (0.80) | KDM4EALDH1A1SMN1; SMN2ALOX15HSD17B10 | |
| SCHEMBL890347 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2ALOX15HSD17B10 | |
| SCHEMBL10929437 | 0.81 | SMN1; SMN2 (0.71) | KDM4EALDH1A1SMN1; SMN2ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9491962-B2 | Use of chicoric acid and derivatives for regulating skin pigmentation | NESTEC S.A. (CH) | 2016-11-15 | — | — | US | disclosed |
| US-9192554-B2 | Use of chicoric acid and lactic bacterium in food supplement for regulating skin pigmentation | NESTEC S.A. (CH) | 2015-11-24 | — | — | US | disclosed |
| US-20130108601-A1 | USE OF CHICORIC ACID AND LACTIC BACTERIUM IN FOOD SUPPLEMENT FOR REGULATING SKIN PIGMENTATION | L'OREAL (FR) | 2013-05-02 | — | — | US | disclosed |
| US-20130095070-A1 | USE OF CHICORIC ACID AND DERIVATIVES FOR REGULATING SKIN PIGMENTATION | L'OREAL (FR) | 2013-04-18 | — | — | US | disclosed |
| WO-2012000954-A1 | USE OF CHICORIC ACID AND DERIVATIVES FOR REGULATING SKIN PIGMENTATION | NESTEC S.A. (CH) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012000960-A1 | USE OF CHICORIC ACID AND DERIVATIVES FOR REGULATING SKIN PIGMENTATION | NESTEC S.A. (CH) | 2012-01-05 | — | — | WO | disclosed |
| WO-2010086322-A1 | COMPOSITION COMPRISING CHICORIC ACID AND/OR DERIVATIVES THEREOF | NESTEC S.A. (CH) | 2010-08-05 | — | — | WO | disclosed |
| EP-2210504-A1 | Composition comprising chicoric acid and/or derivatives thereof | Nestec S.A. (CH) | 2010-07-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130108601-A1 | USE OF CHICORIC ACID AND LACTIC BACTERIUM IN FOOD SUPPLEMENT FOR REGULATING SKIN PIGMENTATION | TYR, LCT, MITF | KDM4E 1797/4885ALDH1A1 511/4885SMN1; SMN2 4133/4885 |
| US-20130095070-A1 | USE OF CHICORIC ACID AND DERIVATIVES FOR REGULATING SKIN PIGMENTATION | TYR, MITF, MC1R | KDM4E 1238/4885ALDH1A1 1463/4885SMN1; SMN2 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.