Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.43 |
| ▸ | MMP13 | P45452 | 7/20 | 0.43 |
| ▸ | MMP14 | P50281 | 4/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP10 | P09238 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305973 | 0.88 | MEN1 (0.43) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL2409029 | 0.88 | MMP1 (0.50) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL7304697 | 0.87 | MMP1 (0.54) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6995243 | 0.80 | MMP1 (0.46) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7313882 | 0.78 | MMP1 (0.55) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6266578 | 0.76 | ADAM17 (0.43) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7312678 | 0.75 | MMP1 (0.43) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL7304591 | 0.75 | MMP1 (0.64) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL27463203 | 0.75 | MMP1 (0.41) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL7308927 | 0.75 | MMP1 (0.50) | MMP1MMP13MMP14MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |