Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 7/20 | 0.40 |
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | MMP14 | P50281 | 4/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 4/20 | 0.40 |
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP10 | P09238 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2409029 | 0.88 | MMP1 (0.50) | ALDH1A1MMP1MMP13MMP14MMP2 | |
| SCHEMBL7303606 | 0.88 | MMP1 (0.43) | ALDH1A1MMP1MMP13MMP14MMP2 | |
| SCHEMBL7305199 | 0.85 | KMT2A (0.39) | MEN1KMT2AALDH1A1MMP1MMP13 | |
| SCHEMBL7313882 | 0.81 | MMP1 (0.55) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL7304697 | 0.77 | MMP1 (0.54) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL7304591 | 0.77 | MMP1 (0.64) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL7306941 | 0.77 | MMP1 (0.64) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6266578 | 0.76 | ADAM17 (0.43) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7311124 | 0.75 | MMP1 (0.41) | MEN1KMT2AALDH1A1MMP1MMP13 | |
| SCHEMBL7308927 | 0.75 | MMP1 (0.50) | ALDH1A1MMP1MMP13MMP14MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |