Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.55 |
| ▸ | MMP13 | P45452 | 12/20 | 0.55 |
| ▸ | MMP2 | P08253 | 8/20 | 0.55 |
| ▸ | MMP3 | P08254 | 6/20 | 0.55 |
| ▸ | MMP9 | P14780 | 6/20 | 0.55 |
| ▸ | MMP8 | P22894 | 6/20 | 0.55 |
| ▸ | MMP14 | P50281 | 7/20 | 0.51 |
| ▸ | MMP7 | P09237 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | MMP10 | P09238 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304697 | 0.89 | MMP1 (0.54) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7304591 | 0.89 | MMP1 (0.64) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7305973 | 0.81 | MEN1 (0.43) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL3941951 | 0.79 | ADAM17 (0.54) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL2409029 | 0.78 | MMP1 (0.50) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7303606 | 0.78 | MMP1 (0.43) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7306093 | 0.78 | MMP1 (0.81) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7308927 | 0.75 | MMP1 (0.50) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7310855 | 0.75 | MMP13 (0.56) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL13898934 | 0.74 | MMP13 (0.48) | MMP1MMP13MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |