Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303099 | 0.90 | HTR2C (0.81) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7298088 | 0.84 | HTR2C (1.00) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7296642 | 0.79 | HTR2C (1.00) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7296823 | 0.77 | HTR2C (0.75) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL8567807 | 0.77 | HTR2C (0.72) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7298654 | 0.77 | HTR2C (0.86) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7303868 | 0.77 | HTR1A (1.00) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7298486 | 0.75 | HTR2C (1.00) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL8880281 | 0.71 | HTR2C (0.66) | HTR2CHTR1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL28226906 | 0.67 | ALDH1A1 (0.77) | HTR2CHTR1AMAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573360-B1 | Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists | ADIR (FR) | 1998-08-26 | — | — | EP | disclosed |
| EP-0573360-A1 | Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists | ADIR ET COMPAGNIE (FR) | 1993-12-08 | — | — | EP | disclosed |