Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060694 | 0.80 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CSMN1; SMN2RAB9A | |
| SCHEMBL23194500 | 0.79 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CSMN1; SMN2RAB9A | |
| SCHEMBL26633385 | 0.78 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CSMN1; SMN2RAB9A | |
| SCHEMBL21033196 | 0.72 | NPC1 (0.62) | SMN1; SMN2RAB9ANPC1TP53KMT2A | |
| SCHEMBL12909529 | 0.71 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL21032816 | 0.70 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL21032819 | 0.70 | MAPT (0.44) | ADRA2AADRA2BADRA2CSMN1; SMN2RAB9A | |
| SCHEMBL21033678 | 0.69 | RAB9A (0.53) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL14657808 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2MAPTTP53HTTKMT2A | |
| SCHEMBL29791389 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2MAPTTP53HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556008-B1 | Condensed imidazopyridine derivatives with psychotropic activity | SHIONOGI & CO (JP) | 1997-05-14 | — | — | EP | disclosed |
| US-5461062-A | Psychotropic agent as antianxiety agent, anesthesia antagonistic agent | SHIONOGI & CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5378848-A | Benzodiazepine agonist, psychotropic, antianxiety, cerebral function activator, anesthesia atagonist | SHIONOGI & CO., LTD. (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0556008-A1 | Condensed imidazopyridine derivatives with psychotropic activity | SHIONOGI & CO., LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |