Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | AR | P10275 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9858859 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2MEN1KMT2ANPC1TSHR | |
| SCHEMBL24287482 | 0.81 | AR (0.50) | SMN1; SMN2MEN1KMT2ANPC1TSHR | |
| SCHEMBL7294576 | 0.81 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1HSP90AA1L3MBTL1 | |
| SCHEMBL8993442 | 0.81 | MEN1 (0.53) | SMN1; SMN2MEN1KMT2ANPC1TSHR | |
| SCHEMBL22724729 | 0.76 | PAX8 (0.51) | SMN1; SMN2MEN1KMT2ANPC1TSHR | |
| SCHEMBL19484600 | 0.75 | HSP90AA1 (0.51) | SMN1; SMN2KMT2ARAB9AALDH1A1HSP90AA1 | |
| SCHEMBL28796696 | 0.73 | LMNA (0.55) | SMN1; SMN2MEN1KMT2ANPC1TSHR | |
| SCHEMBL29692562 | 0.73 | LMNA (0.55) | SMN1; SMN2MEN1KMT2ANPC1TSHR | |
| SCHEMBL1415796 | 0.72 | PAX8 (0.47) | SMN1; SMN2MEN1KMT2ANPC1TSHR | |
| SCHEMBL1748539 | 0.72 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |