Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794785 | 0.81 | KCNH2 (0.38) | LSSKCNH2HRH3LTA4HSMN1; SMN2 | |
| SCHEMBL9705736 | 0.76 | TTR (0.46) | LSSKCNH2HRH3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9705714 | 0.74 | TTR (0.45) | LSSKCNH2HRH3LTA4HSMN1; SMN2 | |
| SCHEMBL7519297 | 0.72 | KCNH2 (0.34) | LSSKCNH2HRH3LTA4HSMN1; SMN2 | |
| SCHEMBL6670692 | 0.72 | KCNH2 (0.34) | LSSKCNH2HRH3LTA4H | |
| SCHEMBL1817200 | 0.72 | LSS (0.51) | LSSKCNH2HRH3LTA4H | |
| SCHEMBL12375094 | 0.72 | KCNH2 (0.34) | KCNH2HRH3LTA4HSMN1; SMN2KCNN4 | |
| SCHEMBL132013 | 0.72 | KCNH2 (0.49) | LSSKCNH2HRH3LTA4HSMN1; SMN2 | |
| SCHEMBL23309639 | 0.71 | KCNH2 (0.33) | KCNH2HRH3LTA4H | |
| SCHEMBL8554944 | 0.70 | CHRNB4 (0.47) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | claimed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | claimed |
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |