Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 3/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17363890 | 0.89 | NR3C1 (0.42) | NR3C2NR3C1FFAR1PPARGPPARD | |
| SCHEMBL17363948 | 0.89 | NR3C1 (0.42) | NR3C2NR3C1FFAR1PPARGPPARD | |
| SCHEMBL17363934 | 0.89 | NR3C1 (0.42) | NR3C2NR3C1FFAR1PPARGPPARD | |
| SCHEMBL8546869 | 0.83 | MMP12 (0.42) | NR3C2NR3C1FFAR1PPARGPPARD | |
| SCHEMBL7295833 | 0.83 | AKR1B1 (0.44) | NR3C2NR3C1FFAR1AKR1B1CYP19A1 | |
| SCHEMBL27663129 | 0.82 | CHEK1 (0.42) | CHEK1CYP19A1MAOB | |
| SCHEMBL7307373 | 0.80 | MTNR1A (0.43) | FFAR1PPARGPPARDHCRTR2CYP19A1 | |
| SCHEMBL7300283 | 0.80 | CHEK1 (0.38) | NR3C2NR3C1CHEK1HCRTR2CYP19A1 | |
| SCHEMBL7414453 | 0.80 | CA2 (0.37) | NR3C2NR3C1CHEK1CYP19A1MAOB | |
| SCHEMBL7298355 | 0.80 | GAA (0.52) | PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666260-B1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |
| EP-0614893-B1 | Benzoxazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1998-05-27 | — | — | EP | disclosed |
| US-5550125-A | BRAIN DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | disclosed |
| EP-0666260-A1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1995-08-09 | — | — | EP | disclosed |
| EP-0614893-A1 | Benzoazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-09-14 | — | — | EP | disclosed |