Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308323 | 0.76 | TSHR (0.37) | — | |
| SCHEMBL7638239 | 0.73 | MEN1 (0.43) | CHEK1MAPT | |
| SCHEMBL7313645 | 0.71 | HSD17B10 (0.39) | BCHEMAPTSMN1; SMN2 | |
| SCHEMBL1298434 | 0.70 | MAPT (0.61) | BCHEMAPTHTTSMN1; SMN2 | |
| SCHEMBL24181414 | 0.67 | GPR88 (0.31) | — | |
| SCHEMBL7639831 | 0.65 | BCHE (0.40) | BCHECHEK1CDK1MAPTHTT | |
| SCHEMBL15952330 | 0.64 | CYP2A6 (0.42) | — | |
| SCHEMBL11278762 | 0.63 | MAPT (0.53) | BCHEMAPTHTTSMN1; SMN2TLR4 | |
| SCHEMBL6572503 | 0.63 | FNTA (0.42) | BCHECHEK1CDK1MAPTHTT | |
| SCHEMBL18507295 | 0.63 | KMO (0.47) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455529-B1 | OXAZOLIDIN-2-ONE DERIVATIVES; ANTICOAGULANTS; ANTIMETASTASIS, ANTICARCINOGENIC, ANTIISCHEMIC, AND ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS, ARTERIOSCLEROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-09-24 | — | — | US | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |